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Alpha-1 Adrenergic Receptors are Localized on Presynaptic Elements in the Nucleus Accumbens and Regulate Mesolimbic Dopamine Transmission

Brainstem noradrenergic neurons innervate the mesocorticolimbic reward pathway both directly and indirectly, with norepinephrine facilitating dopamine (DA) neurotransmission via α1-adrenergic receptors (α1ARs). Although α1AR signaling in the prefrontal cortex (PFC) promotes mesolimbic transmission a...

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Bibliografische gegevens
Hoofdauteurs: Mitrano, Darlene A, Schroeder, Jason P, Smith, Yoland, Cortright, James J, Bubula, Nancy, Vezina, Paul, Weinshenker, David
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398716/
https://ncbi.nlm.nih.gov/pubmed/22588352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2012.68
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