Alpha-1 Adrenergic Receptors are Localized on Presynaptic Elements in the Nucleus Accumbens and Regulate Mesolimbic Dopamine Transmission

Brainstem noradrenergic neurons innervate the mesocorticolimbic reward pathway both directly and indirectly, with norepinephrine facilitating dopamine (DA) neurotransmission via α1-adrenergic receptors (α1ARs). Although α1AR signaling in the prefrontal cortex (PFC) promotes mesolimbic transmission a...

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Bibliografiset tiedot
Päätekijät: Mitrano, Darlene A, Schroeder, Jason P, Smith, Yoland, Cortright, James J, Bubula, Nancy, Vezina, Paul, Weinshenker, David
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2012
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Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398716/
https://ncbi.nlm.nih.gov/pubmed/22588352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2012.68
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