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Effects of the Polo-like-kinase-1-inhibitor BI2536 in squamous cell carcinoma cell lines of the head and neck

Inhibition of the Polo-like-kinase-1 (PLK1) has been shown to be effective in a number of solid tumor models. In this in vitro study, we examined the antitumor effect of BI2536, a small molecule inhibitor of PLK1, in squamous cell carcinoma of the head and neck (SCCHN) cell lines. Dose escalation st...

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Detalhes bibliográficos
Main Authors: WAGENBLAST, JENS, HIRTH, DANIEL, THRON, LAURA, ARNOLDNER, CHRISTOPH, DIENSTHUBER, MARC, STÖVER, TIMO, HAMBEK, MARKUS
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398357/
https://ncbi.nlm.nih.gov/pubmed/22807983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2012.700
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