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A theoretical investigation on the sequence selective binding of mitoxantrone to double-stranded tetranucleotides.

Theoretical computations are performed on the comparative binding energetics of mitoxantrone (MX), a newly synthesized intercalating anthraquinone antitumor drug, to six representative double-stranded tetranucleotides: d(GCGC)2, d(CGCG)2, d(ATAT)2, d(TATA)2, d(GTGT), d(ACAC), and d(CCGG)2. The compu...

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Bibliografiske detaljer
Main Authors: Chen, K X, Gresh, N, Pullman, B
Format: Artigo
Sprog:Inglês
Udgivet: 1986
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC339816/
https://ncbi.nlm.nih.gov/pubmed/3714497
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