Novel Process of Intrathymic Tumor-Immune Tolerance through CCR2-Mediated Recruitment of Sirpα(+) Dendritic Cells: A Murine Model

Immune surveillance system can detect more efficiently secretory tumor-specific antigens, which are superior as a target for cancer immunotherapy. On the contrary, immune tolerance can be induced in the thymus when a tumor antigen is massively secreted into circulation. Thus, the secretion of tumor-...

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Main Authors: Baba, Tomohisa, Badr, Mohamed El Sherif, Tomaru, Utano, Ishizu, Akihiro, Mukaida, Naofumi
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397991/
https://ncbi.nlm.nih.gov/pubmed/22815949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041154
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