R-Spondin Potentiates Wnt/β-Catenin Signaling through Orphan Receptors LGR4 and LGR5

The Wnt/β-catenin signaling pathbway controls many important biological processes. R-Spondin (RSPO) proteins are a family of secreted molecules that strongly potentiate Wnt/β-catenin signaling, however, the molecular mechanism of RSPO action is not yet fully understood. We performed an unbiased siRN...

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Main Authors: Ruffner, Heinz, Sprunger, Joëlle, Charlat, Olga, Leighton-Davies, Juliet, Grosshans, Bianka, Salathe, Adrian, Zietzling, Svenja, Beck, Valérie, Therier, Maxime, Isken, Andrea, Xie, Yang, Zhang, Yue, Hao, Huaixiang, Shi, Xiaoying, Liu, Dong, Song, Qinhui, Clay, Ieuan, Hintzen, Gabriele, Tchorz, Jan, Bouchez, Laure C., Michaud, Gregory, Finan, Peter, Myer, Vic E., Bouwmeester, Tewis, Porter, Jeff, Hild, Marc, Bassilana, Fred, Parker, Christian N., Cong, Feng
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397969/
https://ncbi.nlm.nih.gov/pubmed/22815884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040976
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