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The Impact of Small Molecule Binding on the Energy Landscape of the Intrinsically Disordered Protein C-Myc
Intrinsically disordered proteins are attractive therapeutic targets owing to their prevalence in several diseases. Yet their lack of well-defined structure renders ligand discovery a challenging task. An intriguing example is provided by the oncoprotein c-Myc, a transcription factor that is over ex...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2012
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3397933/ https://ncbi.nlm.nih.gov/pubmed/22815918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041070 |
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