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A small molecule causes a population shift in the conformational landscape of an intrinsically disordered protein
Intrinsically disordered proteins (IDPs) have roles in myriad biological processes and numerous human diseases. However, kinetic and amplitude information regarding their ground-state conformational fluctuations have remained elusive. We demonstrate using nuclear magnetic resonance (NMR)-based relax...
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| Udgivet i: | J Am Chem Soc |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5962290/ https://ncbi.nlm.nih.gov/pubmed/28885015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b01380 |
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