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Critical Determinants of Human α-Defensin 5 Activity against Non-enveloped Viruses

Human α-defensins, such as human α-defensin 5 (HD5), block infection of non-enveloped viruses, including human adenoviruses (AdV), papillomaviruses (HPV), and polyomaviruses. Through mutational analysis of HD5, we have identified arginine residues that contribute to antiviral activity against AdV an...

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Hlavní autoři: Gounder, Anshu P., Wiens, Mayim E., Wilson, Sarah S., Lu, Wuyuan, Smith, Jason G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397880/
https://ncbi.nlm.nih.gov/pubmed/22637473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.354068
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