Monomer-Monomer Interactions Propagate Structural Transitions Necessary for Pore Formation by the Cholesterol-dependent Cytolysins

The assembly of the cholesterol-dependent cytolysin (CDC) oligomeric pore complex requires a complex choreography of secondary and tertiary structural changes in domain 3 (D3) of the CDC monomer structure. A point mutation was identified in the archetype CDC, perfringolysin O, that blocks detectable...

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Main Authors: Hotze, Eileen M., Wilson-Kubalek, Elizabeth, Farrand, Allison J., Bentsen, Lori, Parker, Michael W., Johnson, Arthur E., Tweten, Rodney K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Microbiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397878/
https://ncbi.nlm.nih.gov/pubmed/22645132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.380139
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