Limonoid Compounds Inhibit Sphingomyelin Biosynthesis by Preventing CERT Protein-dependent Extraction of Ceramides from the Endoplasmic Reticulum

To identify novel inhibitors of sphingomyelin (SM) metabolism, a new and selective high throughput microscopy-based screening based on the toxicity of the SM-specific toxin, lysenin, was developed. Out of a library of 2011 natural compounds, the limonoid, 3-chloro-8β-hydroxycarapin-3,8-hemiacetal (C...

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Bibliographische Detailangaben
Hauptverfasser: Hullin-Matsuda, Françoise, Tomishige, Nario, Sakai, Shota, Ishitsuka, Reiko, Ishii, Kumiko, Makino, Asami, Greimel, Peter, Abe, Mitsuhiro, Laviad, Elad L., Lagarde, Michel, Vidal, Hubert, Saito, Tamio, Osada, Hiroyuki, Hanada, Kentaro, Futerman, Anthony H., Kobayashi, Toshihide
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Lipids
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397866/
https://ncbi.nlm.nih.gov/pubmed/22605339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.344432
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