Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

Electrophysiological and pharmacological studies coupled with molecular identification have revealed a unique network of ion channels—Kv1.3, KCa3.1, CRAC (Orai1 + Stim1), TRPM7, Cl(swell)—in lymphocytes that initiates and maintains the calcium signaling cascade required for activation. The expressio...

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Main Authors: Chi, Victor, Pennington, Michael W., Norton, Raymond S., Tarcha, Eric, Londono, Luz, Sims-Fahey, Brian, Upadhyay, Sanjeev K., Lakey, Jonathan T., Iadonato, Shawn, Wulff, Heike, Beeton, Christine, Chandy, K. George
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397671/
https://ncbi.nlm.nih.gov/pubmed/21867724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxicon.2011.07.016
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