Alpha-thalassemia due to the deletion of nucleotides -2 and -3 preceding the AUG initiation codon affects translation efficiency both in vitro and in vivo.

We previously hypothesized that a 2 nucleotide deletion, causing a A-greater than C change at position -3 preceding the ATG initiation codon of alpha globin gene, reduced translation efficiency of alpha globin mRNA and was responsible for a form of alpha + thalassemia displayed by an Algerian patien...

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Bibliographic Details
Main Authors: Morle, F, Starck, J, Godet, J
Format: Artigo
Language:Inglês
Published: 1986
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC339764/
https://ncbi.nlm.nih.gov/pubmed/3703675
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