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Alpha-thalassemia due to the deletion of nucleotides -2 and -3 preceding the AUG initiation codon affects translation efficiency both in vitro and in vivo.

We previously hypothesized that a 2 nucleotide deletion, causing a A-greater than C change at position -3 preceding the ATG initiation codon of alpha globin gene, reduced translation efficiency of alpha globin mRNA and was responsible for a form of alpha + thalassemia displayed by an Algerian patien...

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Foilsithe in:Nucleic Acids Res
Main Authors: Morle, F, Starck, J, Godet, J
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 1986
Rochtain Ar Líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC339764/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3703675/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/14.8.3279
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