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Selective estrogen receptor modulation in pancreatic β-cells and the prevention of type 2 diabetes
We recently showed that the female hormone 17β-estradiol (E2) protects against β-cell failure in rodent models of type 2 diabetes (T2D) by suppressing islet fatty acids and glycerolipids synthesis, thus preventing lipotoxic β-cell failure. E2 anti-lipogenic actions were recapitulated by pharmacologi...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Landes Bioscience
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3396704/ https://ncbi.nlm.nih.gov/pubmed/22543247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/isl.19747 |
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