Sustained Exendin-4 Secretion through Gene Therapy Targeting Salivary Glands in Two Different Rodent Models of Obesity/Type 2 Diabetes

Exendin-4 (Ex-4) is a Glucagon-like peptide 1 (GLP-1) receptor agonist approved for the treatment of Type 2 Diabetes (T2DM), which requires daily subcutaneous administration. In T2DM patients, GLP-1 administration is reported to reduce glycaemia and HbA1c in association with a modest, but significan...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Di Pasquale, Giovanni, Dicembrini, Ilaria, Raimondi, Laura, Pagano, Claudio, Egan, Josephine M., Cozzi, Andrea, Cinci, Lorenzo, Loreto, Andrea, Manni, Maria E., Berretti, Silvia, Morelli, Annamaria, Zheng, Changyu, Michael, Drew G., Maggi, Mario, Vettor, Roberto, Chiorini, John A., Mannucci, Edoardo, Rotella, Carlo M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2012
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396615/
https://ncbi.nlm.nih.gov/pubmed/22808093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040074
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