Sustained Exendin-4 Secretion through Gene Therapy Targeting Salivary Glands in Two Different Rodent Models of Obesity/Type 2 Diabetes

Exendin-4 (Ex-4) is a Glucagon-like peptide 1 (GLP-1) receptor agonist approved for the treatment of Type 2 Diabetes (T2DM), which requires daily subcutaneous administration. In T2DM patients, GLP-1 administration is reported to reduce glycaemia and HbA1c in association with a modest, but significan...

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Detalhes bibliográficos
Main Authors: Di Pasquale, Giovanni, Dicembrini, Ilaria, Raimondi, Laura, Pagano, Claudio, Egan, Josephine M., Cozzi, Andrea, Cinci, Lorenzo, Loreto, Andrea, Manni, Maria E., Berretti, Silvia, Morelli, Annamaria, Zheng, Changyu, Michael, Drew G., Maggi, Mario, Vettor, Roberto, Chiorini, John A., Mannucci, Edoardo, Rotella, Carlo M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396615/
https://ncbi.nlm.nih.gov/pubmed/22808093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040074
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