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On the mechanism and rate of gold incorporation into thiol-dependent flavoreductases
NADPH-dependent flavoreductases are important drug targets. During their enzymatic cycle thiolates and selenolates that have high affinity for transition metals are generated. Auranofin (AF), a gold-containing compound, is classified by the World Health Organization as an antirheumatic agent and it...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3396563/ https://ncbi.nlm.nih.gov/pubmed/22166353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2011.11.005 |
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