Dynamics of TGF-β signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4

The TGF-β pathway plays a vital role in development and disease and regulates transcription through a complex composed of receptor-regulated Smads (R-Smads) and Smad4. Extensive biochemical and genetic studies argue that the pathway is activated through R-Smad phosphorylation; however, the dynamics...

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Bibliographic Details
Main Authors: Warmflash, Aryeh, Zhang, Qixiang, Sorre, Benoit, Vonica, Alin, Siggia, Eric D., Brivanlou, Ali H.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396545/
https://ncbi.nlm.nih.gov/pubmed/22689943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207607109
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