Genome-wide analysis of glucocorticoid receptor-binding sites in myotubes identifies gene networks modulating insulin signaling

Glucocorticoids elicit a variety of biological responses in skeletal muscle, including inhibiting protein synthesis and insulin-stimulated glucose uptake and promoting proteolysis. Thus, excess or chronic glucocorticoid exposure leads to muscle atrophy and insulin resistance. Glucocorticoids propaga...

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Bibliographic Details
Main Authors: Kuo, Taiyi, Lew, Michelle J., Mayba, Oleg, Harris, Charles A., Speed, Terence P., Wang, Jen-Chywan
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396543/
https://ncbi.nlm.nih.gov/pubmed/22733784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111334109
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