Transgenic Anopheles stephensi coexpressing single-chain antibodies resist Plasmodium falciparum development

Anopheles stephensi mosquitoes expressing m1C3, m4B7, or m2A10 single-chain antibodies (scFvs) have significantly lower levels of infection compared to controls when challenged with Plasmodium falciparum, a human malaria pathogen. These scFvs are derived from antibodies specific to a parasite chitin...

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Bibliografiska uppgifter
Huvudupphovsmän: Isaacs, Alison T., Jasinskiene, Nijole, Tretiakov, Mikhail, Thiery, Isabelle, Zettor, Agnès, Bourgouin, Catherine, James, Anthony A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2012
Ämnen:
PNAS Plus
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396534/
https://ncbi.nlm.nih.gov/pubmed/22689959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207738109
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