Oriented nucleation of hemozoin at the digestive vacuole membrane in Plasmodium falciparum

Heme detoxification is a critical step in the life cycle of malaria-causing parasites, achieved by crystallization into physiologically insoluble hemozoin. The mode of nucleation has profound implications for understanding the mechanism of action of antimalarial drugs that inhibit hemozoin growth. S...

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Bibliographic Details
Main Authors: Kapishnikov, Sergey, Weiner, Allon, Shimoni, Eyal, Guttmann, Peter, Schneider, Gerd, Dahan-Pasternak, Noa, Dzikowski, Ron, Leiserowitz, Leslie, Elbaum, Michael
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396484/
https://ncbi.nlm.nih.gov/pubmed/22745164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118120109
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