A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly in anti-citrullinated peptide antibody-negative disease

OBJECTIVE: We sought clinically relevant predictive biomarkers present in CD4 T-cells, or in serum, that identified those patients with undifferentiated arthritis (UA) who subsequently develop rheumatoid arthritis (RA). METHODS: Total RNA was isolated from highly purified peripheral blood CD4 T cell...

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Detalhes bibliográficos
Main Authors: Pratt, Arthur G, Swan, Daniel C, Richardson, Sarah, Wilson, Gillian, Hilkens, Catharien M U, Young, David A, Isaacs, John D
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2012
Assuntos:
Basic and Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396452/
https://ncbi.nlm.nih.gov/pubmed/22532634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2011-200968
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