Footprinting reveals that nogalamycin and actinomycin shuffle between DNA binding sites.
The hypothesis that sequence-selective DNA-binding antibiotics locate their preferred binding sites by a process involving migration from nonspecific sites has been tested by footprinting with DNAase I. Footprinting patterns on the tyrT DNA fragment produced by nogalamycin and actinomycin change wit...
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| Published in: | Nucleic Acids Res |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
1986
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| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC339639/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2421246/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/14.5.2001 |
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