Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis

INTRODUCTION: Cecal ligation and puncture (CLP) is an inflammatory condition that leads to multisystemic organ failure. Flavocoxid, a dual inhibitor of cyclooxygenase (COX-2) and 5-lipoxygenase (5-LOX), has been shown in vitro to possess antiinflammatory activity in lipopolysaccharide (LPS)-stimulat...

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Hauptverfasser: Bitto, Alessandra, Minutoli, Letteria, David, Antonio, Irrera, Natasha, Rinaldi, Mariagrazia, Venuti, Francesco S, Squadrito, Francesco, Altavilla, Domenica
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396211/
https://ncbi.nlm.nih.gov/pubmed/22356547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1364-8535-16-R32
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