Flavocoxid Inhibits Phospholipase A2, Peroxidase Moieties of the Cyclooxygenases (COX), and 5-Lipoxygenase, Modifies COX-2 Gene Expression, and Acts as an Antioxidant

The multiple mechanisms of action for flavocoxid relating to arachidonic acid (AA) formation and metabolism were studied in vitro. Flavocoxid titrated into rat peritoneal macrophage cultures inhibited cellular phospholipase A2 (PLA(2)) (IC(50) = 60 μg/mL). In in vitro enzyme assays, flavocoxid showe...

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Detalhes bibliográficos
Main Authors: Burnett, Bruce P., Bitto, Alessandra, Altavilla, Domenica, Squadrito, Francesco, Levy, Robert M., Pillai, Lakshmi
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134205/
https://ncbi.nlm.nih.gov/pubmed/21765617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/385780
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