Flavocoxid Inhibits Phospholipase A2, Peroxidase Moieties of the Cyclooxygenases (COX), and 5-Lipoxygenase, Modifies COX-2 Gene Expression, and Acts as an Antioxidant

The multiple mechanisms of action for flavocoxid relating to arachidonic acid (AA) formation and metabolism were studied in vitro. Flavocoxid titrated into rat peritoneal macrophage cultures inhibited cellular phospholipase A2 (PLA(2)) (IC(50) = 60 μg/mL). In in vitro enzyme assays, flavocoxid showe...

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Détails bibliographiques
Auteurs principaux: Burnett, Bruce P., Bitto, Alessandra, Altavilla, Domenica, Squadrito, Francesco, Levy, Robert M., Pillai, Lakshmi
Format: Artigo
Langue:Inglês
Publié: Hindawi Publishing Corporation 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134205/
https://ncbi.nlm.nih.gov/pubmed/21765617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/385780
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