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Disruption of the AKT Pathway Inhibits Metastasis in an Orthotopic Model of Head and Neck Squamous Cell Carcinoma
INTRODUCTION: Merck's MK-2206 is an orally active, allosteric inhibitor of AKT; a component of the phosphatidylinositol-3 kinase (PI3K) pathway. The PI3K-AKT pathway is a downstream signaling pathway that has recently been found to play an important role in head and neck squamous cell carcinoma...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3396129/ https://ncbi.nlm.nih.gov/pubmed/22020886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/lary.22180 |
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