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Disruption of the AKT Pathway Inhibits Metastasis in an Orthotopic Model of Head and Neck Squamous Cell Carcinoma

INTRODUCTION: Merck's MK-2206 is an orally active, allosteric inhibitor of AKT; a component of the phosphatidylinositol-3 kinase (PI3K) pathway. The PI3K-AKT pathway is a downstream signaling pathway that has recently been found to play an important role in head and neck squamous cell carcinoma...

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Bibliographic Details
Main Authors: Knowles, Joseph A, Golden, Blake, Yan, Li, Carroll, William R., Helman, Emily E., Rosenthal, Eben L.
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396129/
https://ncbi.nlm.nih.gov/pubmed/22020886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/lary.22180
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