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Blocking of PDL-1 Interaction Enhances Primary and Secondary CD8 T Cell Response to Herpes Simplex Virus-1 Infection

The blocking of programmed death ligand-1 (PDL-1) has been shown to enhance virus-specific CD8 T cell function during chronic viral infections. Though, how PDL-1 blocking at the time of priming affects the quality of CD8 T cell response to acute infections is not well understood and remains controve...

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Détails bibliographiques
Auteurs principaux: Channappanavar, Rudragouda, Twardy, Brandon S., Suvas, Susmit
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395688/
https://ncbi.nlm.nih.gov/pubmed/22808056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039757
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