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Numbl inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-κB activation

The Notch signaling regulator Numblike (Numbl) is expressed in the brain, but little is known regarding its role in the pathophysiology of glial cells. In this paper, we report that Numbl expression was down-regulated in high-grade human glioma tissue samples and glioblastoma cell lines. To investig...

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Hlavní autoři: Tao, Tao, Cheng, Chun, Ji, Yuhong, Xu, Guangfei, Zhang, Jianguo, Zhang, Li, Shen, Aiguo
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395653/
https://ncbi.nlm.nih.gov/pubmed/22593207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-09-0805
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