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miRNA-like duplexes as RNAi triggers with improved specificity

siRNA duplexes, the most common triggers of RNA interference, are first loaded into an Argonaute (Ago) protein and then undergo unwinding via passenger strand cleavage, which requires the slicer activity of the Ago protein. In mammals, only Ago2 out of the four Ago proteins possesses such slicer act...

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Detalles Bibliográficos
Main Authors: Betancur, Juan G., Yoda, Mayuko, Tomari, Yukihide
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Research Foundation 2012
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395129/
https://ncbi.nlm.nih.gov/pubmed/22807929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2012.00127
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