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miRNA-like duplexes as RNAi triggers with improved specificity
siRNA duplexes, the most common triggers of RNA interference, are first loaded into an Argonaute (Ago) protein and then undergo unwinding via passenger strand cleavage, which requires the slicer activity of the Ago protein. In mammals, only Ago2 out of the four Ago proteins possesses such slicer act...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Frontiers Research Foundation
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3395129/ https://ncbi.nlm.nih.gov/pubmed/22807929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2012.00127 |
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