Severe Injury Is Associated With Insulin Resistance, Endoplasmic Reticulum Stress Response, and Unfolded Protein Response

OBJECTIVE: We determined whether postburn hyperglycemia and insulin resistance are associated with endoplasmic reticulum (ER) stress/unfolded protein response (UPR) activation leading to impaired insulin receptor signaling. BACKGROUND: Inflammation and cellular stress, hallmarks of severely burned a...

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Autori principali: Jeschke, Marc G., Finnerty, Celeste C., Herndon, David N., Song, Juquan, Boehning, Darren, Tompkins, Ronald G., Baker, Henry V., Gauglitz, Gerd G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395076/
https://ncbi.nlm.nih.gov/pubmed/22241293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SLA.0b013e31823e76e7
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