Metabolic Flux Increases Glycoprotein Sialylation: Implications for Cell Adhesion and Cancer Metastasis

This study reports a global glycoproteomic analysis of pancreatic cancer cells that describes how flux through the sialic acid biosynthetic pathway selectively modulates a subset of N-glycosylation sites found within cellular proteins. These results provide evidence that sialoglycoprotein patterns a...

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Autors principals: Almaraz, Ruben T., Tian, Yuan, Bhattarcharya, Rahul, Tan, Elaine, Chen, Shih-Hsun, Dallas, Matthew R., Chen, Li, Zhang, Zhen, Zhang, Hui, Konstantopoulos, Konstantinos, Yarema, Kevin J.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394959/
https://ncbi.nlm.nih.gov/pubmed/22457533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.017558
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