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Anti-CD180 (RP105) activates B cells to rapidly produce polyclonal Ig via a T cell and MyD88-independent pathway

CD180 is homologous to TLR4 and regulates TLR4 signaling, yet its function is unclear. We report that injection of anti-CD180 mAb into mice induced rapid Ig production of all classes and subclasses except IgA and IgG2b, with up to 50-fold increases of serum IgG1 and IgG3. IgG production after anti-C...

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Detalhes bibliográficos
Main Authors: Chaplin, Jay W., Kasahara, Shinji, Clark, Edward A., Ledbetter, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394853/
https://ncbi.nlm.nih.gov/pubmed/21918197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100198
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