Ubiquitylation of Terminal Deoxynucleotidyltransferase Inhibits Its Activity

Terminal deoxynucleotidyltransferase (TdT), which template-independently synthesizes DNA during V(D)J recombination in lymphoid cells, is ubiquitylated by a BPOZ-2/Cul3 complex, as the ubiquitin ligase, and then degraded by the 26 S proteasome. We show here that TdT is ubiquitylated by the Cul3-base...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Maezawa, So, Fukushima, Rie, Matsushita, Toyofumi, Kato, Tomoyoshi, Takagaki, Yoshiki, Nishiyama, Yoshihiro, Ando, Sachiko, Matsumoto, Takuro, Kouda, Kousuke, Hayano, Takahide, Suzuki, Masahiro, Koiwai, Kotaro, Koiwai, Osamu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394778/
https://ncbi.nlm.nih.gov/pubmed/22808041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039511
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados