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Oxidative and Endoplasmic Reticulum Stresses Mediate Apoptosis Induced by Modified LDL in Human Retinal Müller Cells

PURPOSE. We previously showed that extravasated, modified LDL is implicated in pericyte loss in diabetic retinopathy (DR). Here, we investigate whether modified LDL induces apoptosis in retinal Müller glial cells. METHODS. Cultured human retinal Müller cells (MIO-M1) were treated with highly oxidize...

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Detalhes bibliográficos
Main Authors: Wu, Mingyuan, Yang, Shihe, Elliott, Michael H., Fu, Dongxu, Wilson, Kenneth, Zhang, Jing, Du, Mei, Chen, Junping, Lyons, Timothy
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394695/
https://ncbi.nlm.nih.gov/pubmed/22678501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.12-9910
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