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Synthesis of (±)-7-Hydroxylycopodine

A seven-step synthesis of (±)-7-hydroxylycopodine that proceeds in 5% overall yield has been achieved. The key step is a Prins reaction in 60% sulfuric acid that gave the key tricyclic intermediate with complete control of the ring fusion stereochemistry. A one-pot procedure orthogonally protected t...

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Main Authors: Lin, Hong-Yu, Causey, Robert, Garcia, Gregory E., Snider, Barry B.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393807/
https://ncbi.nlm.nih.gov/pubmed/22443298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo300353t
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