The Carmaphycins, New Proteasome Inhibitors Exhibiting an α,β-Epoxyketone Warhead from a Marine Cyanobacterium

Two new peptidic proteasome inhibitors were isolated as trace components from a Curaçao collection of Symploca sp. marine cyanobacteria. Carmaphycin A (1) and carmaphycin B (2) feature a leucine-derived α, β -epoxyketone warhead directly connected to either methionine sulfoxide or methionine sulfone...

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Autors principals: Pereira, Alban R., Kale, Andrew J., Fenley, Andrew T., Byrum, Tara, Debonsi, Hosana M., Gilson, Michael K., Valeriote, Frederick A., Moore, Bradley S., Gerwick, William H.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393770/
https://ncbi.nlm.nih.gov/pubmed/22383253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201200007
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