Enzyme inhibition by hydroamination: Design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor

Hydroamination reactions involving the addition of an amine to an inactivated alkene are entropically prohibited and require strong chemical catalysts. While this synthetic process is efficient at generating substituted amines, there is no equivalent in small molecule-mediated enzyme inhibition. Her...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Trivella, Daniela B. B., Pereira, Alban R., Stein, Martin L., Kasai, Yusuke, Byrum, Tara, Valeriote, Frederick A., Tantillo, Dean J., Groll, Michael, Gerwick, William H., Moore, Bradley S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4103027/
https://ncbi.nlm.nih.gov/pubmed/24930969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.04.010
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