Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design

A fragment-based screen against human immunodeficiency virus type 1 (HIV) integrase led to a number of compounds that bound to the lens epithelium derived growth factor (LEDGF) binding site of the integrase catalytic core domain. We determined the crystallographic structures of complexes of the HIV...

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Autores principales: Peat, Thomas S., Rhodes, David I., Vandegraaff, Nick, Le, Giang, Smith, Jessica A., Clark, Lisa J., Jones, Eric D., Coates, Jonathan A. V., Thienthong, Neeranat, Newman, Janet, Dolezal, Olan, Mulder, Roger, Ryan, John H., Savage, G. Paul, Francis, Craig L., Deadman, John J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393750/
https://ncbi.nlm.nih.gov/pubmed/22808106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040147
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