Trypanosoma brucei gambiense Group 1 Is Distinguished by a Unique Amino Acid Substitution in the HpHb Receptor Implicated in Human Serum Resistance

Trypanosoma brucei rhodesiense (Tbr) and T. b. gambiense (Tbg), causative agents of Human African Trypanosomiasis (sleeping sickness) in Africa, have evolved alternative mechanisms of resisting the activity of trypanosome lytic factors (TLFs), components of innate immunity in human serum that protec...

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Bibliographic Details
Main Authors: Symula, Rebecca E., Beadell, Jon S., Sistrom, Mark, Agbebakun, Kehinde, Balmer, Oliver, Gibson, Wendy, Aksoy, Serap, Caccone, Adalgisa
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393672/
https://ncbi.nlm.nih.gov/pubmed/22802982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001728
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