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Enhanced mRNA cap methylation increases Cyclin D1 expression and promotes cell transformation
Cap-dependent mRNA translation requires the methylation of the mRNA guanosine cap by RNA guanine-7-methyltransferase (RNMT). mRNA cap methylation was recently described to be rate-limiting for a subset of mRNAs, and to be enhanced by expression of c-Myc and E2F1, although the biological significance...
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3393636/ https://ncbi.nlm.nih.gov/pubmed/19915615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.368 |
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