Multifunctional CD4 Cells Expressing Gamma Interferon and Perforin Mediate Protection against Lethal Influenza Virus Infection

CD4 effectors generated in vitro can promote survival against a highly pathogenic influenza virus via an antibody-independent mechanism involving class II-restricted, perforin-mediated cytotoxicity. However, it is not known whether CD4 cells activated during influenza virus infection can acquire cyt...

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Bibliographic Details
Main Authors: Brown, Deborah M., Lee, Sarah, Garcia-Hernandez, Maria de la Luz, Swain, Susan L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393557/
https://ncbi.nlm.nih.gov/pubmed/22491469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07172-11
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