Structural Insight into the Unique Properties of Adeno-Associated Virus Serotype 9

Adeno-associated virus serotype 9 (AAV9) has enhanced capsid-associated tropism for cardiac muscle and the ability to cross the blood-brain barrier compared to other AAV serotypes. To help identify the structural features facilitating these properties, we have used cryo-electron microscopy (cryo-EM)...

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Autori principali: DiMattia, Michael A., Nam, Hyun-Joo, Van Vliet, Kim, Mitchell, Matthew, Bennett, Antonette, Gurda, Brittney L., McKenna, Robert, Olson, Norman H., Sinkovits, Robert S., Potter, Mark, Byrne, Barry J., Aslanidi, George, Zolotukhin, Sergei, Muzyczka, Nicholas, Baker, Timothy S., Agbandje-McKenna, Mavis
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Structure and Assembly
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393551/
https://ncbi.nlm.nih.gov/pubmed/22496238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07232-11
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