Mice Deficient in STAT1 but Not STAT2 or IRF9 Develop a Lethal CD4(+) T-Cell-Mediated Disease following Infection with Lymphocytic Choriomeningitis Virus

Interferon (IFN) signaling is crucial for antiviral immunity. While type I IFN signaling is mediated by STAT1, STAT2, and IRF9, type II IFN signaling requires only STAT1. Here, we studied the roles of these signaling factors in the host response to systemic infection with lymphocytic choriomeningiti...

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Detalhes bibliográficos
Main Authors: Hofer, Markus J., Li, Wen, Manders, Peter, Terry, Rachael, Lim, Sue Ling, King, Nicholas J. C., Campbell, Iain L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393544/
https://ncbi.nlm.nih.gov/pubmed/22496215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07147-11
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