IRF9 Prevents CD8(+) T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection

Effective CD8(+) T cell responses play an important role in determining the course of a viral infection. Overwhelming antigen exposure can result in suboptimal CD8(+) T cell responses, leading to chronic infection. This altered CD8(+) T cell differentiation state, termed exhaustion, is characterized...

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Publicado en:J Virol
Autores principales: Huber, Magdalena, Suprunenko, Tamara, Ashhurst, Thomas, Marbach, Felix, Raifer, Hartmann, Wolff, Svenja, Strecker, Thomas, Viengkhou, Barney, Jung, So Ri, Obermann, Hannah-Lena, Bauer, Stefan, Xu, Haifeng C., Lang, Philipp A., Tom, Adomati, Lang, Karl S., King, Nicholas J. C., Campbell, Iain L., Hofer, Markus J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2017
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660491/
https://ncbi.nlm.nih.gov/pubmed/28878077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01219-17
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