Identification of a Divalent Metal Cation Binding Site in Herpes Simplex Virus 1 (HSV-1) ICP8 Required for HSV Replication

Herpes simplex virus 1 (HSV-1) ICP8 is a single-stranded DNA-binding protein that is necessary for viral DNA replication and exhibits recombinase activity in vitro. Alignment of the HSV-1 ICP8 amino acid sequence with ICP8 homologs from other herpesviruses revealed conserved aspartic acid (D) and gl...

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Bibliographic Details
Main Authors: Bryant, Kevin F., Yan, Zhipeng, Dreyfus, David H., Knipe, David M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393532/
https://ncbi.nlm.nih.gov/pubmed/22491472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00374-12
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