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Enantioselective total synthesis of (+)-ibophyllidine via an asymmetric phosphine-catalyzed [3 + 2] annulation

In this study we performed the total synthesis of the terpene indole alkaloid (+)-ibophyllidine through a pathway involving asymmetric phosphine catalysis, with our novel l-4-hydroxyproline–derived chiral phosphine mediating the key [3 + 2] annulation. Hydrogenation of the [3 + 2] adduct allowed the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Andrews, Ian P., Kwon, Ohyun
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393134/
https://ncbi.nlm.nih.gov/pubmed/22798981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C2SC20468A
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